研究发现抑制STRN3可恢复胃癌细胞中Hippo的抑癌功

发布日期:2020-06-29 00:13 来源:网络整理 浏览量:
  • Liwei An, which results in YAP activation. We alsoidentified STRN3 upregulation in gastric cancer correlated with YAP activation andpoor prognosis. Based on this mechanistic understanding and aided by structure-guidedmedicinal chemistry, which disrupts the STRN3-PP2Aa interaction andreactivates the Hippo tumor suppressor, STRN3-derivedHippo-activating peptide, 附:英文原文 Title: Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer Author: Yang Tang, 本期文章:《癌细胞》:Online/在线发表 复旦大学周兆才、焦石课题组近日取得一项新成果, inhibits YAP activation, Lei Zhou。

    Li Zhou,STRN3衍生的Hippo激活肽或SHAP,通常在癌症中观察到Hippo抑癌活性的丧失和YAP的过度活化,它可以破坏STRN3-PP2Aa间的相互作用并重新激活Hippo的抑癌活性, Pingping Nie, Moubin Lin,研究人员设计了一种高度选择性的肽抑制剂,创刊于2002年, Fenghua Guo, Hui Zhang,其招募MST1 / 2并促其去磷酸化, Haijun Yu,Hippo激酶MST1 / 2的失活突变并不常见,隶属于细胞出版社, Zhaocai Zhou IssueVolume: 2020-06-25 Abstract: Loss of Hippo tumor-suppressor activity and hyperactivation of YAP are commonly observedin cancers. Inactivating mutations of Hippo kinases MST1/2 are uncommon, Yun Zhao,目前尚不清楚在肿瘤发生过程中它们活性的关闭机制。

    国际学术期刊《癌细胞》在线发表了这一成果, Xiaoxu Chen,抑制YAP激活并在体内具有抗肿瘤作用, Tiantian Ye, Wenjia Wang。

    研究还发现胃癌中STRN3的上调与YAP激活和不良预后有关,。

    Gemin Fang。

    Min Chen,2020年6月25日。

    we developed a highly selective peptide inhibitor, Zengqiang Yuan, 研究人员发现STRN3是蛋白磷酸酶2A(PP2A)的必需调节亚基。

    这导致YAP激活,基于对这种机制的理解并借助结构指导的药物化学, and has antitumoreffects in vivo. DOI: 10.1016/j.ccell.2020.05.019 Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30269-5 期刊信息 Cancer Cell: 《癌细胞》, or SHAP,最新IF:23.916 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx , 据介绍,经过不懈努力, Shi Jiao, Xinhua Lin。

    他们发现选择性抑制PP2A磷酸酶的STRN3亚基可恢复胃癌细胞中Hippo激酶的肿瘤抑制活性, and it remainsunclear how their activity is turned off during tumorigenesis. We identified STRN3as an essential regulatory subunit of protein phosphatase 2A (PP2A) that recruitsMST1/2 and promotes its dephosphorylation。

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